Antiplatelet therapy: focus on evidence-based therapy with clopidogrel
نویسندگان
چکیده
منابع مشابه
Acute Coronary Syndrome: Focus on Antiplatelet Therapy.
The American Heart Association/American College of Cardiology in 2014 published a focused update of the 2007 and 2012 guidelines for non-ST-segment elevation acute coronary syndrome (NSTE-ACS). The management of ST-segment elevation myocardial infarction (STEMI) is described in a separate guideline published in 2013. The focused updates to the guidelines contain updated recommendations for dual...
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The use of antiplatelet agents, specifically the thienopyridines, has become a standard of care in the approach to the patient presenting with an acute coronary syndrome. These drugs irreversibly inhibit the platelet by permanently binding to the surface P2Y12 receptor and blocking the downstream fibrinogen cross-linking between platelets, which leads to aggregation and thrombus. However, curre...
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BACKGROUND Dual antiplatelet therapy using acetylsalicylic acid (ASA, aspirin) and clopidogrel is of great importance following coronary stenting. However, the variable platelet inhibitory effectiveness compromises the antithrombotic advantages provided by dual antiplatelet therapy. The aim of this single-center prospective study was to reduce the low response incidence of dual antiplatelet the...
متن کاملAntiplatelet effects of clopidogrel compared with aspirin after myocardial infarction: enhanced inhibitory effects of combination therapy.
OBJECTIVES We sought to compare the inhibitory effects of the combination of two doses of aspirin plus clopidogrel with either drug alone on platelet aggregation and activation. BACKGROUND Enhanced platelet inhibitory effects of clopidogrel by aspirin on platelet aggregation and activation are suggested by experimental studies but have not been shown in humans. METHODS The effects of clopid...
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background: clopidogrel is one of the most commonly prescribed drugs to prevent ischemic events following coronary syndromes or stent placement. however, impaired responses to therapy as well as resistance are also reported. genetic variants play an important role in clopidogrel biotransformation to its active metabolite that may subsequently influence the clopidogrel antiplatelet effect. the o...
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ژورنال
عنوان ژورنال: Cardiologia Croatica
سال: 2013
ISSN: 1848-543X,1848-5448
DOI: 10.15836/ccar.2013.74